Indication: Weight gain (postmenopausal women)


Source: Arch Intern Med, May 14, 2007;167(9):893-902.

Research:
A randomized, double-blind, placebo-controlled trial was performed with 36,282 postmenopausal women, aged 50 to 79 years, who were already enrolled in the dietary modification and/or hormone therapy arms of the Women’s Health Initiative clinical trial. Women were randomized at their first or second annual visit to receive a dose of 1000 mg of elemental calcium plus 400 IU of cholecalciferol (vitamin D) or placebo daily. Change in body weight was ascertained annually for an average of 7 years.

Results:
Women receiving calcium plus cholecalciferol supplements vs. women receiving placebo had a minimal but consistent favorable difference in weight change. After 3 years of follow-up, women with daily calcium intakes less than 1200 mg at baseline who were randomized to supplements were 11% less likely to experience small weight gains (1-3 kg) and 11% less likely to gain more moderate amounts of weight. The greatest benefits were seen in women who began the study with inadequate calcium intakes—those consuming less than the current recommendation of 1200 mg of calcium per day. As a result, researchers believe these latest findings do not justify altering current dietary recommendations, and that postmenopausal women should continue to be advised to consume 1200 mg a day of calcium.